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Original articles

  1. Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S.Crystal structure of the anion exchanger domain of human erythrocyte band 3.Science. 2015 Nov 6;350(6261):680-4.
  2. Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D.Structure and mechanism of the mammalian fructose transporter GLUT5.Nature. 2015 Sep 30.
  3. Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y.High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with NMO-IgG.Br J Pharmacol. 2015 Sep 23.
  4. Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.Analysis of the subcellular localization of the human histone methyltransferase SETDB1.Biochem Biophys Res Commun. 2015 Oct 2;465(4):725-31.
  5. Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H.MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.Stem Cell Reports. 2015 Sep 8;5(3):365-77.
  6. Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts.PLoS One. 2015 May 27;10(5):e0125468. eCollection 2015.
  7. Morita M, Sekine A, Urano Y, Nishimura T, Takabe W, Arai H, Hamakubo T, Kodama T, Noguchi N.Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.J Biochem. 2015 Oct;158(4):331-8.
  8. Csincsi ÁI, Kopp A, Zöldi M, Bánlaki Z, Uzonyi B, Hebecker M, Caesar JJ, Pickering MC, Daigo K, Hamakubo T, Lea SM, Goicoechea de Jorge E, Józsi M.Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.J Immunol. 2015 May 15;194(10):4963-73.Epub 2015 Apr 8.
  9. Nakayama T, Mizohata E, Yamashita T, Nagatoishi S, Nakakido M, Iwanari H, Mochizuki Y, Kado Y, Yokota Y, Satoh R, Tsumoto K, Fujitani H, Kodama T, Hamakubo T, Inoue T.Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.Protein Sci.2015 Mar;24(3):328-40.
  10. Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N. Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor.Monoclon Antib Immunodiagn Immunother.2014 Dec;33(6):378-85.
  11. Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M.Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsyNature Medicine.Published online 08 December 2014
  12. Nishimura T, Kawamura T, Sugihara Y, Bando Y, Sakamoto S, Nomura M, Ikeda N, Ohira T, Fujimoto J, Tojo H, Hamakubo T, Kodama T, Andersson R, Fehniger TE, Kato H, Marko-Varga G Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank RepositoriesClin Transl Med.2014 Nov 22;3(1):61. eCollection 2014.
  13. Razvina O, Jiang S, Matsubara K, Ohashi R, Hasegawa G, Aoyama T, Daigo K, Kodama T, Hamakubo T, Naito M Differential expression of pentraxin 3 in neutrophils.Exp Mol Pathol. 2014 Nov 20. pii: S0014-4800(14)00184-1.
  14. Daigo K, Nakakido M, Ohashi R, Fukuda R, Matsubara K, Minami T, Yamaguchi N, Inoue K, Jiang S, Naito M, Tsumoto K, Hamakubo T. Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis
    Sci. Signal., 16 September 2014; Vol. 7, Issue 343, p. ra88
    /Editor's Summary /Abstract /Full Text
  15. Ohsuka S, Ohba A, Onoda S, Nakamoto K, Nakano T, Miyoshi M, Soda K, Hamakubo T. Laboratory-size three-dimensional x-ray microscope with Wolter type I mirror optics and an electron-impact water window x-ray sourceRev. Sci. Instrum.2014;85;093701
  16. Hamakubo T, Kusano-Arai O, Iwanari H. Generation of antibodies against membrane proteins. Biochim Biophys Acta. 2014 Aug 15. pii: S1570-9639(14)00205-2.
  17. Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T. A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy. EJNMMI Res. 2014 Jun 1;4:29
  18. Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T. Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.Mol Pharmacol. 2014 Sep;86(3):252-62.
  19. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PPARβ/δ activation of CD300a controls intestinal immunity.Sci Rep.2014 Jun 24;4:5412.
  20. Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. J Neuropathol Exp Neurol.2014 Jul;73(7):714-28.
  21. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.PLoS One.2014 May 5;9(5):e96005.
  22. Daigo K, Mantovani A, Bottazzi B. The yin-yang of long pentraxin PTX3 in inflammation and immunity Immunology Letters.2014 Sep;161(1):38-43
  23. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells.PLoS One.2014 May 5;9(5):e96005.
  24. Akiba H, Sumaoka J, Hamakubo T, Komiyama M. Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex.Anal Bioanal Chem. 2014 May;406(12):2957-64.
  25. Kudo S, Caaveiro JM, Goda S, Nagatoishi S, Ishii K, Matsuura T, Sudou Y, Kodama T, Hamakubo T, Tsumoto K. Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion.Biochemistry.2014 Mar 25;53(11):1742-52.
  26. Aramaki S, Hayashi K, Kurimoto K, Ohta H, Yabuta Y, Iwanari H, Mochizuki Y, Hamakubo T, Kato Y, Shirahige K, Saitou M. A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.Dev Cell.2013 Dec 9;27(5):516-29.
  27. Iida M, Yoshida T, Watari A, Yagi K, Hamakubo T, Kondoh M. A baculoviral display system to assay viral entry.Biol Pharm Bull.2013;36(11):1867-9.
  28. Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J Biol Chem.2013 Nov 15;288(46):33292-302.
  29. Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. G protein-dependent basal and evoked endothelial cell vWF secretion. Blood. 2014 Jan 16;123(3):442-50.
  30. Ramadhanti J, Huang P, Kusano-Arai O, Iwanari H, Sakihama T, Misu T, Fujihara K, Hamakubo T, Yasui M, Abe Y. A novel monoclonal antibody against the C-terminal region of aquaporin-4. Monoclon Antib Immunodiagn Immunother. 2013 Aug;32(4):270-6.
  31. Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29.
  32. Miyazaki K, Abe Y, Iwanari H, Suzuki Y, Kikuchi T, Ito T, Kato J, Kusano-Arai O, Takahashi T, Nishiyama S, Ikeshima-Kataoka H, Tsuji S, Arimitsu T, Kato Y, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M. Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4. J Neuroimmunol. 2013 Jul 15;260(1-2):107-16.
  33. Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, Iwanari H, Ushio-Fukai M, Fukai T. Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury. Arterioscler Thromb Vasc Biol. 2013 Jan 24.
  34. Daigo K, Hamakubo T. Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps. Front Immunol. 2012;3:378.
  35. Yumura K, Ui M, Doi H, Hamakubo T, Kodama T, Tsumoto K, Sugiyama A.  Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin. Protein Sci. 2013 Feb;22(2):213-21.
  36. Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M, Hamakubo T. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. J Biol Chem. 2013 Jan 11;288(2):1009-21.
  37. Kusano-Arai O, Iwanari H, Mochizuki Y, Nakata H, Kodama T, Kitoh T, Hamakubo T. Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies. Hybridoma (Larchmt). 2012 Oct;31(5):325-32.
  38. Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T. Inhibition of DNA Damage-induced Apoptosis through Cdc7-mediated Stabilization of Tob. J Biol Chem. 2012 Nov 23;287(48):40256-65.
  39. Mitsui K, Sakihama T, Takahashi K, Masuda K, Fukuda R, Hamana H, Sato T, Hamakubo T. Functional reconstitution of olfactory receptor complex on baculovirus. Chem Senses. 2012 Nov;37(9):837-47.
  40. Kudo S, Caaveiro JM, Miyafusa T, Goda S, Ishii K, Matsuura T, Sudou Y, Kodama T, Hamakubo T, Tsumoto K. Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. Mol Biosyst. 2012 Aug;8(8):2050-3.
  41. Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y. Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol. 2012 Aug;32(15):3018-32.
  42. Li Y, Mitsuhashi S, Ikejo M, Miura N, Kawamura T, Hamakubo T, Ubukata M. Relationship between ATM and Ribosomal Protein S6 Revealed by the Chemical Inhibition of Ser/Thr Protein Phosphatase Type 1. Biosci Biotechnol Biochem. , 76(3):486-94., 2012
  43. Takahashi A, Saito Y, Kondoh M, Matsushita K, Krug SM, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M, Hamakubo T, Yagi K., Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials. , 33(12):3464-74., 2012
  44. Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikdeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Wevand S, Shimamura T, Nomura N, Cameron A D, Kobayashi T, Hamakubo T, Iwata S & Murata T. G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature, January 29, 2012
  45. Daigo K,Yamaguchi N, Kawamura T, Matsubara K, Jiang S, Ohashi R, Sudou Y, Kodama T, Naito M, Inoue K, and Hamakubo T. The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps. Mol Cell Proteomics , January 25, 2012
  46. Miyama A, Saito Y, Yamanaka K, Hayashi K, Hamakubo T, Noguchi N. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One. 2011;6(11):e27883. Epub 2011 Nov 21.
  47. Yamagishi H, Mochizuki Y, Hamakubo T, Obata K, Ugajin T, Sato S, Kawano Y, Minegishi Y, Karasuyama H. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun. 2011 Dec 2;415(4):709-13.
  48. Suzuki H, Kondoh M, Kakutani H, Yamane S, Uchida H, Hamakubo T, Yagi K., [Epub ahead of print] The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice. Biomaterials. 2012 Jan;33(1):317-24.
  49. Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 2011 Jul 4. doi: 10.1038/onc.2011.265.
  50. Takahashi A, Kondoh M, Uchida H, Kakamu Y, Hamakubo T, Yagi K. Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro. Biochem Biophys Res Commun. 2011 Jul 8;410(3):466-70.
  51. Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T. Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.
  52. Motoyoshi Baba, Tohru Kozasa, Takao Hamakubo, Hiroto Kuroda, Kazuyuki Masuda, Shin Yoneya and Tatsuhiko Kodama. Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy. Pharmaceuticals 2011, 4(3), 524-550.
  53. Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T. A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells. J Immunol Methods. 2011 Jun 30;369(1-2):108-14. Epub 2011 May 3.
  54. Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T. Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Eur J Cell Biol. 2011 Aug;90(8):657-64.
  55. Savchenko AS, Inoue A, Ohashi R, Jiang S, Hasegawa G, Tanaka T, Hamakubo T, Kodama T, Aoyagi Y, Ushiki T, Naito M. Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis. Pathol Int. 2011 May;61(5):290-7
  56. Kunii R, Jiang S, Hasegawa G, Yamamoto T, Umezu H, Watanabe T, Tsuchida M, Hashimoto T, Hamakubo T, Kodama T, Sasai K, Naito M. The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma. Histopathology. 2011 Feb;58(3):467-76.
  57. Kakutani H, Takahashi A, Kondoh M, Saito Y, Yamaura T, Sakihama T, Hamakubo T, Yagi K. A novel screening system for claudin binder using baculoviral display. PLoS One. 2011 Feb 14;6(2):e16611.
  58. Saravanan G, Daigo K, Imae T, Hamakubo T. Visual observation of avidin-biotin affinity by fluorescent G4.5 poly(amidoamine) dendrimer. Colloids Surf B Biointerfaces. 2011 Mar 1;83(1):58-60. Epub 2010 Nov 2.
  59. Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T. Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem. 2011 Jan 7;286(1):674-86. Epub 2010 Nov 3.
  60. Akazawa YO, Saito Y, Hamakubo T, Masuo Y, Yoshida Y, Nishio K, Shichiri M, Miyasaka T, Iwanari H, Mochizuki Y, Kodama T, Noguchi N, Niki E. Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.Neurosci Lett. 2010 Oct 15;483(3):201-5.
  61. Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, Okano HJ, Okano H. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010 Aug 12;67(3):407-21.
  62. Seki M, Watanabe A, Enomoto S, Kawamura T, Ito H, Kodama T, Hamakubo T, Aburatani H. Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. FEBS Lett. 2010 Jul 2;584(13):2909-15.
  63. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. Biochem J. 2010 Jul 15;429(2):347-57.
  64. Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi K. Mucosal vaccination using claudin-4-targeting. Biomaterials. Biomaterials. 2010 Jul;31(20):5463-71.
  65. Uchida H, Kondoh M, Hanada T, Takahashi A, Hamakubo T, Yagi K. A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol. 2010 May 15;79(10):1437-44
  66. Suehiro J, Hamakubo T, Kodama T, Aird WC, Minami T. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood. 2010 Mar 25;115(12):2520-32.
  67. Wada Y, Ohta Y, Xu M, Tsutsumi S, Minami T, Inoue K, Komura D, Kitakami J, Oshida N, Papantonis A, Izumi A, Kobayashi M, Meguro H, Kanki Y, Mimura I, Yamamoto K, Mataki C, Hamakubo T, Shirahige K, Aburatani H, Kimura H, Kodama T, Cook PR, Ihara S. A wave of nascent transcription on activated human genes. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18357-61.
  68. Tachibana K, Takeuchi K, Inada H, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells. Biochem Biophys Res Commun. 2009 Sep 11.
  69. Saito Y, Hamakubo T, Yoshida Y, Ogawa Y, Hara Y, Fujimura H, Imai Y, Iwanari H, Mochizuki Y, Shichiri M, Nishio K, Kinumi T, Noguchi N, Kodama T, Niki E. Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. Neurosci Lett. 2009 Nov 6;465(1):1-5.
  70. Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against Nicastrin inhibits the {gamma}-secretase activity. J Biol Chem. 2009 Aug 14.
  71. Saeki R, Kondoh M, Kakutani H, Tsunoda S, Mochizuki Y, Hamakubo T, Tsutsumi Y, Horiguchi Y, Yagi K. A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol. 2009 Oct;76(4):918-26.
  72. Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009 Aug;119(8):2257-70.
  73. Komai T, Iwanari H, Mochizuki Y, Hamakubo T, Shinkai Y. Expression of the mouse PR domain protein Prdm8 in the developing central nervous system. Gene Expr Patterns. 2009 Oct;9(7):503-14.
  74. Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol. 2009 Jul 13;186(1):147-60.
  75. Takano K, Hasegawa G, Jiang S, Kurosaki I, Hatakeyama K, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M. Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma. Pathol Int. 2009 Jul;59(7):462-70.
  76. Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells. J Biol Chem. 2009 Aug 14;284(33):22195-205.
  77. Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol. 2009 Jul;29(13):3544-55.
  78. Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5819-24.
  79. Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. Pathol Int. 2009 Mar;59(3):152-60.
  80. Minegishi Y, Iwanari H, Mochizuki Y, Horii T, Hoshino T, Kodama T, Hamakubo T, Gotoh N. Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles. FEBS Lett. 2009 Feb 18;583(4):807-14.
  81. Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M  Protein expression of nuclear receptors in human and murine tissues. Pathol Int. 2009 Feb;59(2):61-72.
  82. Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. A simple detection method for low-affinity membrane protein interactions by baculoviral display. PLoS One. 2008;3(12):e4024.
  83. Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, Mochizuki N  Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem. 2009 Feb 27;284(9):5592-601.
  84. Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, Kodama T, Hamakubo T, Kozasa T. Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. J Biol Chem. 2009 Feb 20;284(8):5000-9.
  85. Ishiguro T, Sugimoto M, Kinoshita Y, Miyazaki Y, Nakano K, Tsunoda H, Sugo I, Ohizumi I, Aburatani H, Hamakubo T, Kodama T, Tsuchiya M, Yamada-Okabe H. Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer. Cancer Res. 2008 Dec 1;68(23):9832-8.
  86. Nakano K, Orita T, Nezu J, Yoshino T, Ohizumi I, Sugimoto M, Furugaki K, Kinoshita Y, Ishiguro T, Hamakubo T, Kodama T, Aburatani H, Yamada-Okabe H, Tsuchiya M. Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2009 Jan 9;378(2):279-84.
  87. Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T. Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. FEBS Lett. 2008 Nov 26;582(28):3884-8.
  88. Sugai M, Umezu H, Yamamoto T, Jiang S, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M. Expression of hepatocyte nuclear factor 4 alpha in primary ovarian mucinous tumors. Pathol Int. 2008 Nov;58(11):681-6.
  89. Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol. 2008 Oct;79(1):1-11.
  90. Ohguchi H, Tanaka T, Uchida A, Magoori K, Kudo H, Kim I, Daigo K, Sakakibara I, Okamura M, Harigae H, Sasaki T, Osborne TF, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J. Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol Cell Biol. 2008 Jun;28(12):3917-31.
  91. Sakihama T, Masuda K, Sato T, Doi T, Kodama T, Hamakubo T. Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J Biotechnol. 2008 May 20;135(1):28-33. Epub 2008 Mar 7.
  92. Yorikawa C, Takaya E, Osako Y, Tanaka R, Terasawa Y, Hamakubo T, Mochizuki Y, Iwanari H, Kodama T, Maeda T, Hitomi K, Shibata H, Maki M. Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments. J Biochem. 2008 Jun;143(6):731-45.
  93. Savchenko A, Imamura M, Ohashi R, Jiang S, Kawasaki T, Hasegawa G, Emura I, Iwanari H, Sagara M, Tanaka T, Hamakubo T, Kodama T, Naito M. Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. J Pathol. 2008 May;215(1):48-55.
  94. Imamura M, Kawasaki T, Savchenko AS, Ohashi R, Jiang S, Miyamoto K, Ito Y, Iwanari H, Sagara M, Tanaka T, Hamakubo T, Kodama T, Uchiyama M, Naito M. Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages. Cell Immunol. 2007 Aug;248(2):86-94. Epub 2007 Nov 28.
  95. Tachibana K, Katayama T, Ueda C, Sumitomo M, Tagami M, Ishimoto K, Yamasaki D, Tanaka T, Hamakubo T, Sakai J, Kodama T, Obika S, Imanishi T, Doi T. Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells. Nucleic Acids Symp Ser (Oxf). 2007;(51):441-2.
  96. Sugiyama A, Wada Y, Izumi A, Kobayashi M, Kohro T, Patrick CR, Hamakubo T, Kodama T. Transcriptional activation by hypoxia and low-density lipoprotein loading in cultured vascular smooth muscle cells. J Atheroscler Thromb. 2007 Oct;14(5):226-34.
  97. Wako K, Kawasaki T, Yamana K, Suzuki K, Jiang S, Umezu H, Nishiyama T, Takahashi K, Hamakubo T, Kodama T, Naito M. Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer. J Clin Pathol. 2008 Apr;61(4):448-54.
  98. Reid PC, Urano Y, Kodama T, Hamakubo T. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med. 2007 May-Jun;11(3):383-92. Review.
  99. Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y. Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1300-6.
  100. Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J. Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol Cell Biol. 2007 Jun;27(12):4248-60.
  101. Saitoh R, Ohtomo T, Yamada Y, Kamada N, Nezu J, Kimura N, Funahashi S, Furugaki K, Yoshino T, Kawase Y, Kato A, Ueda O, Jishage K, Suzuki M, Fukuda R, Arai M, Iwanari H, Takahashi K, Sakihama T, Ohizumi I, Kodama T, Tsuchiya M, Hamakubo T. Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus. J Immunol Methods. 2007 Apr 30;322(1-2):104-17.
  102. Sakamoto A, Kawasaki T, Kazawa T, Ohashi R, Jiang S, Maejima T, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M. Expression of liver X receptor alpha in rat fetal tissues at different developmental stages. J Histochem Cytochem. 2007 Jun;55(6):641-9.
  103. Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M. Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Pathol Int. 2007 Feb;57(2):82-90.
  104. Tachibana K, Anzai N, Ueda C, Katayama T, Kirino T, Takahashi R, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T. Analysis of PPAR alpha function in human kidney cell line using siRNA. Nucleic Acids Symp Ser (Oxf). 2006;(50):257-8.
  105. Inoue K, Sugiyama A, Reid PC, Ito Y, Miyauchi K, Mukai S, Sagara M, Miyamoto K, Satoh H, Kohno I, Kurata T, Ota H, Mantovani A, Hamakubo T, Daida H, Kodama T. Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):161-7.
  106. Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17278-83. Epub 2006 Nov 6.
  107. Inoue K, Kobayashi M, Yano K, Miura M, Izumi A, Mataki C, Doi T, Hamakubo T, Reid PC, Hume DA, Yoshida M, Aird WC, Kodama T, Minami T. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2652-9.
  108. Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. FEBS Lett. 2006 Sep 4;580(20):4929-33. Epub 2006 Aug 14.
  109. Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanabe A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H. Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3257-64.
  110. Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun. 2006 May 5;343(2):525-34.
  111. Daigo K, Sugita S, Mochizuki Y, Iwanari H, Hiraishi K, Miyano K, Kodama T, Hamakubo T. A simple hybridoma screening method for high-affinity monoclonal antibodies using the signal ratio obtained from time-resolved fluorescence assay. Anal Biochem. 2006 Apr 15;351(2):219-28.
  112. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.
    J Pathol. 2006 Jan 6;
  113. Saitoh R, Ohtomo T, Ito Y, Nezu J, Kimura N, Funahashi S, Aso Y, Ohizumi I, Kodama T, Hamakubo T, Tsuchiya M. Recovery of functional peptide transporter PepT1 in budded baculovirus fraction. Protein Expr Purif., Sep 26, 2005.
  114. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T. Gene expression profiling of potential peroxisome proliferators activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing PPAR isoform. Nucl Recept. Oct 3;3(1):3, 2005.
  115. Morikawa S, Murakami T, Yamazaki H, Izumi A, Saito Y, Hamakubo T, Kodama T. Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. J Atheroscler Thromb. 12(3):121-31. 2005.
  116. Akiyama C, Shinozaki-Narikawa N, Kitazawa T, Hamakubo T, Kodama T, Shibasaki Y. Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells. Cell Biol Int. Jul;29(7):514-20. 2005.
  117. Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. Apr 1;19(7):815-26. 2005.
  118. Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma -secretase complex with lipid rafts. J Lipid Res. May;46(5):904-12. 2005.
  119. Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, Katsumi K, Iwanari H, Noguchi N, Naito M, Hamakubo T, Kodama T. Expression of the LXR{alpha} Protein in Human Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol. Mar;25(3):622-7. 2005.
  120. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC. Vascular endothelial growth factor- and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem. Nov 26;279(48):50537-54. 2004.
  121. Ikuo Hayashi, Yasuomi Urano, Rie Fukuda, Noriko Isoo, Tatsuhiko Kodama, Takao Hamakubo, Taisuke Tomita, and Takeshi Iwatsubo. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. J Biol Chem. Sep 3;279(36):38040-6. 2004.
  122. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, Kodama T. A Comparison of Differences in the Gene Expression Profiles of Phorbol 12-myristate 13-acetate Differentiated THP-1 Cells and Human Monocyte-derived Macrophage.
    J Atheroscler Thromb. 11(2):88-97. 2004.
  123. Morikawa S, Takabe W, Mataki C, Wada Y, Izumi A, Saito Y, Hamakubo T, Kodama T. Global analysis of RNA expression profile in human vascular cells treated with statins. J Atheroscler Thromb.;11(2):62-72. 2004.
  124. Hippo Y, Watanabe K, Watanabe A, Midorikawa Y, Yamamoto S, Ihara S, Tokita S, Iwanari H, Ito Y, Nakano K, Nezu J, Tsunoda H, Yoshino T, Ohizumi I, Tsuchiya M, Ohnishi S, Makuuchi M, Hamakubo T, Kodama T, Aburatani H. Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. Cancer Res. Apr 1;64(7):2418-23. 2004.
  125. Minami T, Murakami T, Horiuchi K, Miura M, Noguchi T, Miyazaki J, Hamakubo T, Aird WC, Kodama T. Interaction between Hex and GATA Transcription Factors in Vascular Endothelial Cells Inhibits flk-1/KDR-mediated Vascular Endothelial Growth Factor Signaling. J Biol Chem. May 14;279(20):20626-35. 2004.
  126. Kawahara N, Wang Y, Mukasa A, Furuya K, Shimizu T, Hamakubo T, Aburatani H, Kodama T, Kirino T. Genome-wide gene expression analysis for induced ischemic tolerance and delayed neuronal death following transient global ischemia in rats.
    J Cereb Blood Flow Metab. 24(2):212-23. 2004
  127. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
    Proc Natl Acad Sci U S A. 100(26):15924-9. 2003.
  128. Matsui Y, Saiura A, Sugawara Y, Sata M, Naruse K, Yagita H, Kohro T, Mataki C, Izumi A, Yamaguchi T, Minami T, Sakihama T, Ihara S, Aburatani H, Hamakubo T, Kodama T, Makuuchi M. Identificaton of gene expression profile in tolerizing murine cardiac allograft by co-stimulatory blockade. Physiol Genomics. 15(3):199-208. 2003.
  129. Jiang S, Tanaka T, Iwanari H, Hotta H, Yamashita H, Kumakura J, Watanabe Y, Uchiyama Y, Aburatani H, Hamakubo T, Kodama T, Naito M. Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats.
    Nucl Recept. Aug 8;1(1):5. 2003.
  130. Watanabe Y, Tanaka T, Uchiyama Y, Takeno T, Izumi A, Yamashita H, Kumakura J, Iwanari H, Shu-Ying J, Naito M, Mangelsdorf DJ, Hamakubo T, Kodama T. Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages.
    Nucl Recept. May 9;1(1):1. 2003
  131. Urano Y, Yamaguchi M, Fukuda R, Masuda K, Takahashi K, Uchiyama Y, Iwanari H, Jiang SY, Naito M, Kodama T, Hamakubo T. A novel method for viral display of ER membrane proteins on budded baculovirus.
    Biochem Biophys Res Commun. 308(1):191-6. 2003
  132. Masuda K, Itoh H, Sakihama T, Akiyama C, Takahashi K, Fukuda R, Yokomizo T, Shimizu T, Kodama T, Hamakubo T. A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor. J Biol Chem. 278(27):24552-62. 2003.
  133. Saiura A, Sugawara Y, Harihara Y, Sata M, Hamakubo T, Kodama T, Makuuchi M. Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray. Transpl Int.;15(11):535-40. 2002.
  134. Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman AI, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T. The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J Atheroscler Thromb. 9(5):233-42. 2002.
  135. Wada H, Hashimoto K, Wada Y, Kobayashi M, Izumi A, Sugiyama A, Kohro T, Hamakubo T, Kodama T. Extensive oligonucleotide microarray transcriptome analysis of the rat cerebral artery and arachnoid tissue. J Atheroscler Thromb.; 9(5):224-32. 2002.
  136. Wada Y, Sugiyama A, Yamamoto T, Naito M, Noguchi N, Yokoyama S, Tsujita M, Kawabe Y, Kobayashi M, Izumi A, Kohro T, Tanaka T, Taniguchi H, Koyama H, Hirano K, Yamashita S, Matsuzawa Y, Niki E, Hamakubo T, Kodama T. Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions. Arterioscler Thromb Vasc Biol. 22(10):1712-9. 2002.
  137. Morikawa S, Takabe W, Mataki C, Kanke T, Itoh T, Wada Y, Izumi A, Saito Y, Hamakubo T, Kodama T. The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells. J Atheroscler Thromb. 9(4):178-83. 2002
  138. Uchiyama Y, Huang Y, Kanamori H, Uchida M, Doi T, Takamizawa A, Hamakubo T, Kodama T. Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions. Hepatol Res. 23(2):90-97. 2002
  139. Saiura A, Kohro T, Yamamoto T, Izumi A, Wada Y, Aburatani H, Sugawara Y, Hamakubo T, Taniguchi T, Naito M, Kodama T, Makuuchi M. Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray. Transplantation. 15;73(9):1480-6. 2002.
  140. Inoue K, Cynshi O, Kawabe Y, Nakamura M, Miyauchi K, Kimura T, Daida H, Hamakubo T, Yamaguchi H, Kodama T. Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits. Atherosclerosis. 161(2):353-63. 2002.
  141. Mashiba S, Wada Y, Takeya M, Sugiyama A, Hamakubo T, Nakamura A, Noguchi N, Niki E, Izumi A, Kobayashi M, Uchida K, Kodama T. In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL. Arterioscler Thromb Vasc Biol. 21(11):1801-8. 2001.
  142. Huang Y, Uchiyama Y, Fujimura T, Kanamori H, Doi T, Takamizawa A, Hamakubo T, Kodama T. A human hepatoma cell line expressing hepatitis c virus nonstructural proteins tightly regulated by tetracycline. Biochem Biophys Res Commun. 2;281(3):732-40. 2001.
  143. Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T, Kodama T. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol. 21(6):917-22. 2001.
  144. Saiura A, Mataki C, Murakami T, Umetani M, Wada Y, Kohro T, Aburatani H, Harihara Y, Hamakubo T, Yamaguchi T, Hasegawa G, Naito M, Makuuchi M, Kodama T. A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis. Transplantation. Jul 27;72(2):320-9. 2001.
  145. Takabe W, Kodama T, Hamakubo T, Tanaka K, Suzuki T, Aburatani H, Matsukawa N, Noguchi N. Anti-atherogenic antioxidants regulate the expression and function of proteasome {alpha}-type subunits in human endothelial cells. J Biol Chem. 276(44), 40497-501, 2001.
  146. Kohro T. Nakajima T. Wada Y. Sugiyama A. Ishii M. Tsutsumi S. Aburatani H. Imoto I. Inazawa J. Hamakubo T. Kodama T. and Emi M. Genomic Structure and Mapping of Human Orphan Receptor LXR Alpha: Upreglation of LXRa mRNA During Monocyte to Macrophage Differentiation. Journal of Atherosclerosis and Thrombosis, 7(3), 145-151. 2000.
  147. Morikawa S. Umetani M. Nakagawa S. Yamazaki H. Suganami H. Inoue K. Kitahara M. Hamakubo T., Kodama T. and Saito Y. Relative Induction of mRNA for HMG CoA Reductase and LDL Receptor by five Different HMG CoA Reductase Inhibitors in Cultured Human Cells. Journal of Atherosclerosis and Thrombosis, 7(3), 138-144. 2000
  148. Mataki C. Murakami T. Umetani M. Wada Y. Ishii M. Tsutsumi S. Aburatani H. Hamakubo T. and Kodama T. A Novel Zinc Finger Protein mRNA in Human Umbilical Vein Endothelial Cells is Profoundly Induced by Tumor Necrosis Factor a. Journal of Atherosclerosis and Thrombosis, 7(2), 97-103. 2000.
  149. Murakami T. Mataki C. Nagao C. Umetani M. Wada Y. Ishii M. Tsutsumi S. Kohro T. Saiura A. Aburatani H. Hamakubo T. and Kodama T. The Gene Expression Profile of Human Umbilical Vein Endothelial Cells Stimulated by Tumor Necrosis Factor Using DNA Microarray Analysis. Journal of Atherosclerosis and Thrombosis, 7(1), 39-44. 2000.
  150. Nakajima T, Iwaki K, Hamakubo T, Kodama T, Emi M: Genomic structure of the gene encoding human 3-hydroxy-3-methyl-glutaryl coenzyme A reductase: comparison of exon/intron organization of sterol-sensing domains among four related genes. J Hum Genet, 45(5):284-9. 2000.
  151. Umetani M, Nakao H, Doi T, Iwasaki A, Ohtaka M, Nagoya T, Mataki C, Hamakubo T, Kodama T. A Novel Cell Adhesion Inhibitor, K-7174, Reduces the Endothelial VCAM-1 Induction by Inflammatory Cytokines, Acting through the Regulation of GATA. Biochem Biophys Res Commun. Jun 7;272(2):370-374. 2000.
  152. Shirai H, Murakami T, Yamada Y, Doi T, Hamakubo T, Kodama Structure and function of type I and II macrophage scavenger receptors. TMech Ageing Dev 1999 ;111:107-21
  153. Heigoro Shirai, Mineko Yamaguchi, Ryuichiro Sato, Yoshiki Kawabe, Rie Fukuda, Tatsuhiko Kodama and Takao Hamakubo,. Degradation Enzymes for Sterol Regulatory element Binding Protein; Common Diseases:Genetic and Pathogenic Aspects of Multifunction Diseases (1999),pp131-138. Elsevier Science
  154. Nakajima T., Hamakubo T., Kodama T., Inazawa J., and M. Emi. : Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene. J Hum Genet , 44, pp 402 - 7, 1999.
  155. Takaku M, Wada Y, Jinnouchi K, Takeya M, Takahashi K, Usuda H, Naito M, Kurihara H, Yazaki Y, Kumazawa Y, Okimoto Y, Umetani M, Noguchi N, Niki E, Hamakubo T, Kodama TAn In vitro coculture model of transmigrant monocytes and foam cell formation.Arterioscler Thromb Vasc Biol Oct;19(10):2330-9, 1999.
  156. Yamaguchi, M., Shirai, H., Sato, R., Kawabe,Y., Fukuda, R., Kodama, T., and Hamakubo, T. Characterization of cleaving enzymes for sterol regulatory element binding protein in hamster liver microsomes. Biochem Biophys Res Commun. 258, 542-7, 1999.
  157. Kawabe Y., Suzuki T., Hayashi M., Hamakubo T., Sato R., Kodama T.: The physiological role of sterol regulatory element-binding protein-2 in cultured human cells. Biochimica et Biophysica Acta, 1436, pp307-318, 1999.
  158. Yamada Y, Doi T., Hamakubo T. and T. Kodama"Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system. Cellular and Molecular Life Sciences, 54, pp628-640, 1998
  159. Mosqueda-Garcia, R., Appalsamy M, Fernandez-Violante, R., Hamakubo, T., and R. Stainback. "Modulatory Effects of Endothelin on Baroreflex Activation in the Nucleus of the Solitary Tract" Europian Journal of Pharmacology, 351, pp203-207, 1998
  160. Yasukiyo Mori, Hiroaki Matsubara, Satoshi Murasawa, Kazuhisa Kijima, Katsuya, Maruyama, Hiroyasu Tsukaguchi, Naohiko Okubo, Takao Hamakubo, Tadashi Inagami, Toshiji Iwasaka, Mitsuo Inada. "Translational Regulation of Angiotensin II Type 1A Receptor Role of Upstream AUG Triplets" Hypertension, 28 : 810-817 ,1996
  161. Mosqueda-Garcia, R., Fernandez-Violante, R., Hamakubo, T., and R. Stainback. "Vasopressin mediates the pressor effects of endothelin in the subfornical organ of the rat" Journal of Pharmacology & Experimental Therapeutics, 277(2):1034-1-42, 1996.
  162. Mosqueda-Garcia, R., Stainback, R., Fernandez-Violante, R., and T. Hamakubo "Cardiovascular effects of endothelin in brain nuclei regulating vasopressin release." J Cardiovasc. Pharmacol., 26(suppl 3): S159-S162, 1995.
  163. Kenji Ohyama, Yamano, Y., Sano, T., Nakagomi, Y., Hamakubo, T., Morishima, I., and T. Inagami"Disulfide bridges in extracellular domains of angiotensin II receptor type IA" Regulatory Peptides, 57. 141-147. 1995.
  164. Yamano, Y., Ohyama, K., Kikyo, M., Sano, T., Nakagomi, Y., Inoue, Y., Nakamura, I., Guo, D-F., Hamakubo, T., and T. Inagami."Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)." Journal of Biological Chemistry, 270. pp14024-14030. 1995.
  165. Yoshida, M., Hamakubo, T., and T. Inagami.Angiotensin II-mediated Pressor Effect of Rat Joining Peptide. American Journal of Physiology (Regulatory Integrative Comperative  Physiology. 35), 266, R802-R808. 1994
  166. Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., and T. Inagami.Molecular Cloning of a Novel Angiotensin II Receptor Isoform Involved in Phosphotyrosine Phosphatase Inhibition. Journal of Biological Chemistry, 268; 24543-24546, 1993
  167. Hamakubo, T., Yoshida, M., Nakajima, K., Watanabe, T. X., Mosqueda-Garcia, and T. Inagami. Central Cardiovascular Effects of Joining Peptide in the Genetically Hypertensive Rat. American Journal of Physiology (Regulatory Integrative Comperative Physiology, 34), 265; R1184-R1190, 1993
  168. Hamakubo, T., Furuta, H., Ichimura, M., Appalsamy, M., Mosqueda-Garcia, R., Robertson, D. and T. Inagami.A Na Pump Inhibitor from Bovine Posterior Pituitary: Purification, Structure Determination and Its Cardiovascular effect in rat. Biochemical and Biophysical Research Communications, 189, 691-696; 1992
  169. Shimizu, K., Hamamoto, T., Hamakubo, T., Lee, W. J., Suzuki, K., Nakagawa, Y., Murachi T., and T. Yamamuro.Immunohistochemical and Biochemical Demonstration of Calcium-Dependent Cystein Proteinase (Calpain) in Calcifying Cartilage of Rats. Journal of Orthopaedic Research, 9; 26-36, 1991
  170. Suzuki, K., Shimizu, K., Hamamoto, T., Nakagawa, Y., Hamakubo, T. and T. Yamamuro. Biochemical Demonstration of Calpains and Calpastatin in Osteoarthritic Synovial Fluid. Arthritis and Rheumatism, 33; 728-732, 1990
  171. Kinoshita, M., Hamakubo, T., Fukui, I., Murachi, T., and H. Toyohara.Significant Amount of Multicatalytic Proteinase Identified on Membrane from Human Erythrocyte. Journal of Biochemistry, 107; 440-444, 1990
  172. Hamakubo, T., Ueda, M., Takano, E., and T. Murachi.Distributional and Developmental Variations of Multiple Forms of Calpastatin in Mouse Brain. Journal of Enzyme Inhibition, 3; 203-210, 1990
  173. Takano, E., Hamakubo, T., Kawatani, Y., Ueda, M., Kannagi, R., and T. Murachi. Multiple Forms of Calpastatin in Pig Brain. Biochemistry International, 19; 633-643. 1989
  174. Murachi, T., Murakami, T., Ueda, M., Fukui, I., Hamakubo, T., Adachi, Y., and M. Hatanaka.; "The Calpain-Calpastatin System in Hematopoietic Cells" in Calcium Protein Signaling. (Hidaka, H., Carafoli, E., Means, A. R., and T. Tanaka, eds.), pp445-454. Plenum Publishing Corporation 1989
  175. Ogata, N., Yonekawa, Y., Taki, W., Kannagi, R., Murachi, T., Hamakubo, T., and H. Kikuchi. Degradation of Neurofilament Protein in Cerebral Ischemia. Journal of Neurosurgery, 70; 103-107, 1989
  176. Murakami, T., Ueda, M., Hamakubo, T., and T. Murachi.;Identification of Both Calpains I and II in Nucleated Chicken Erythrocytes. Journal of Biochemistry, 103; 168-171, 1988
  177. Fukui, I., Toyohara, H., Ito, K., Hamakubo, T., and T. Murachi.Molecular and Catalytic Characterization of Intact Heterodimeric and Derived Monomeric Calpains Isolated under Different Conditions from Pig Polymorphonuclear Leukocytes. Biochemistry, 27; 3260-3267, 1988
  178. Murachi, T., Hatanaka, M., and T. Hamakubo. Calpains and Neuropeptide Metabolism. in Neuropeptides and Their Peptidases. (Turner, A. J., ed.), pp202-228.Ellis-Horwood, London. 1987
  179. Hamakubo, T., Ueda, M., Fucharoen, S., Wilairat, P., Pimainork, Y., and T. Murachi. Thalassemic Red Blood Cells and the Study of Membrane Protein. Contemporary Themes in Biochemistry, ICSU Short Reports, 6; 524-525, 1986
  180. Hamakubo, T., Kannagi, R., Murachi, T., and A. Matus.; Distribution of Calpain in Rat Brain. Journal of Neuroscience, 6; 3103-3111, 1986
  181. Miyachi, Y., Yoshimura, N., Suzuki, S., Hamakubo, T., Kannagi, R., Imamura, S., and T. Murachi.Biochemical Demonstration and Immunohistochemical Localization of Calpain in Human Skin. Journal of Investigative Dermatology, 86; 346-349, 1986
  182. Yoshimura, N., Ohtuki, H., Hamakubo, T., Kitahara, A., Kannagi, R., and T. Murachi.Distribution of Calpain in Various Organs of Rat: An Immunohistochemical Study. Biomedical Research, 5; 419-425, 1984

著書 / Books

  1. 考える血管(児玉龍彦,浜窪隆雄):講談社,1997
  2. 浜窪隆雄,児玉龍彦:プロテインチップの開発とプロテオミクス,「プロテオミクス」;伊藤隆司,谷口壽章編,167-181頁,中山書店,2000
  3. 浜窪隆雄:心臓血管系,「予防医学事典」;松島綱治,酒井敏行,石川昌,稲寺秀邦編,373-37 5頁,朝倉書店, 2005
  4. 「タンパク質の事典」 猪飼篤・伏見譲・卜部格・中村春木・浜窪隆雄 編 朝倉書店 2008年
  5. 「分子細胞生物学辞典」 第2版 村松正實 他編 東京化学同人 2008年
  6. 浜窪隆雄:抗体医薬の現状と課題,「次世代医薬開発に向けた抗体工学の最前線」;熊谷泉 監修,1-8頁,シーエムシー出版,2012年
  7. 浜窪隆雄:機能性抗体の作製と医薬探索への応用技術,「抗体医薬品の開発と市場」;石田功 他著,12-26頁,2012年
  8. 「新機能抗体開発ハンドブック」 浜窪隆雄 監修 NTS,2012年